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The human brain reactivates context-specific past information at event boundaries of naturalistic experiences

Hahamy, Avital; Dubossarsky, Haim; Behrens, Timothy; (2023) The human brain reactivates context-specific past information at event boundaries of naturalistic experiences. Nature Neuroscience , 26 pp. 1080-1089. 10.1038/s41593-023-01331-6. Green open access

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Abstract

Although we perceive the world in a continuous manner, our experience is partitioned into discrete events. However, to make sense of these events, they must be stitched together into an overarching narrative – a model of unfolding events. It has been proposed that such a stitching process happens in offline neural reactivations when rodents build models of spatial environments. Here we show that, whilst understanding a natural narrative, humans reactivate neural representations of past events. Similar to offline replay, these reactivations occur in hippocampus and default mode network, where reactivations are selective to relevant past events. However, these reactivations occur, not during prolonged offline periods, but at the boundaries between ongoing narrative events. These results, replicated across two datasets, suggest reactivations as a candidate mechanism for binding temporally distant information into a coherent understanding of ongoing experience.

Type: Article
Title: The human brain reactivates context-specific past information at event boundaries of naturalistic experiences
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41593-023-01331-6
Publisher version: https://doi.org/10.1038/s41593-023-01331-6
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. - This research was funded in whole, or in part, by the Wellcome Trust (Grant number 214314/Z/18/Z and 219525/Z/19/Z). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10169068
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