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Development of a robust and efficient manufacturing process for improved production of chimeric antigen receptor T cell (CAR-T) immunotherapies

Hood, Tiffany Tamara; (2023) Development of a robust and efficient manufacturing process for improved production of chimeric antigen receptor T cell (CAR-T) immunotherapies. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Abstract

Ex vivo genetically-modified cellular immunotherapies, such as chimeric antigen receptor T-(CAR-T) cell therapies, have generated significant clinical and commercial outcomes due to their unparalleled response rates against relapsed and refractory blood cancers. However, the development and manufacture of these novel therapies face a number of translational bottlenecks that must be addressed to ensure long-term commercial viability. This work aimed to develop a more robust and efficient expansion process for the production of clinically relevant CAR-T cells using quality by design (QbD) principles. This thesis demonstrates how systematic process development and implementation of automation with effective process monitoring and control capability can significantly improve CAR-T production to address current manufacturing limitations.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Development of a robust and efficient manufacturing process for improved production of chimeric antigen receptor T cell (CAR-T) immunotherapies
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2022. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10168836
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