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Dexmedetomidine improves success of paediatric MRI sedation

Jackson, Thomas J; Dawes, Deborah; Ahmad, Shaista; Martin, Darren; Gyamtso, Cassandra; (2022) Dexmedetomidine improves success of paediatric MRI sedation. Archives of Disease in Childhood , 107 (7) pp. 692-694. 10.1136/archdischild-2021-322734. Green open access

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Abstract

OBJECTIVE: To improve success rates of children requiring sedation for MRI. METHODS: Audits of sedation success for children attending planned MRI using three different approaches: (1) National Institute for Health and Care Excellence (NICE) guidance (chloral hydrate if <15 kg and oral midazolam if ≥15 kg), (2) Chloral hydrate for all patients, (3) Chloral hydrate±intranasal dexmedetomidine if <15 kg and intranasal dexmedetomidine alone if ≥15 kg. RESULTS: 74 patients had 85 MRI scan attempts. Overall success rates were significantly higher when using intranasal dexmedetomidine compared with following NICE guidance (81% vs 52% p=0.017). Dexmedetomidine performed better than oral midazolam for the same indication (76% vs 33% p=0.026). The side effect profile for dexmedetomidine was as reported in larger studies. CONCLUSIONS: Intranasal dexmedetomidine is an effective alternative to oral midazolam for sedation for MRI and as a rescue medication where chloral hydrate has been ineffective.

Type: Article
Title: Dexmedetomidine improves success of paediatric MRI sedation
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/archdischild-2021-322734
Publisher version: http://dx.doi.org/10.1136/archdischild-2021-322734
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10168780
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