Lezmy, Jonathan;
(2023)
How astrocytic ATP shapes neuronal activity and brain circuits.
Current Opinion in Neurobiology
, 79
, Article 102685. 10.1016/j.conb.2023.102685.
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Abstract
Astrocytes play a key role in processing information at synapses, by controlling synapse formation, modulating synapse strength and terminating neurotransmitter action. They release ATP to shape brain activity but it is unclear how, as astrocyte processes contact many targets and ATP-mediated effects are diverse and numerous. Here, I review recent studies showing how astrocytic ATP modulates cellular mechanisms in nearby neurons and glia in the grey and white matter, how it affects signal transmission in these areas, and how it modulates behavioural outputs. I attempt to provide a flowchart of astrocytic ATP signalling, showing that it tends to inhibit neural circuits to match energy demands.
| Type: | Article |
|---|---|
| Title: | How astrocytic ATP shapes neuronal activity and brain circuits |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.conb.2023.102685 |
| Publisher version: | https://doi.org/10.1016/j.conb.2023.102685 |
| Language: | English |
| Additional information: | Crown Copyright © 2023 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10168510 |
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