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How astrocytic ATP shapes neuronal activity and brain circuits

Lezmy, Jonathan; (2023) How astrocytic ATP shapes neuronal activity and brain circuits. Current Opinion in Neurobiology , 79 , Article 102685. 10.1016/j.conb.2023.102685. Green open access

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Abstract

Astrocytes play a key role in processing information at synapses, by controlling synapse formation, modulating synapse strength and terminating neurotransmitter action. They release ATP to shape brain activity but it is unclear how, as astrocyte processes contact many targets and ATP-mediated effects are diverse and numerous. Here, I review recent studies showing how astrocytic ATP modulates cellular mechanisms in nearby neurons and glia in the grey and white matter, how it affects signal transmission in these areas, and how it modulates behavioural outputs. I attempt to provide a flowchart of astrocytic ATP signalling, showing that it tends to inhibit neural circuits to match energy demands.

Type: Article
Title: How astrocytic ATP shapes neuronal activity and brain circuits
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.conb.2023.102685
Publisher version: https://doi.org/10.1016/j.conb.2023.102685
Language: English
Additional information: Crown Copyright © 2023 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10168510
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