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Insights into the metastatic cascade through research autopsies

Hessey, Sonya; Fessas, Petros; Zaccaria, Simone; Jamal-Hanjani, Mariam; Swanton, Charles; (2023) Insights into the metastatic cascade through research autopsies. Trends Cancer 10.1016/j.trecan.2023.03.002. Green open access

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Abstract

Metastasis is a complex process and the leading cause of cancer-related death globally. Recent studies have demonstrated that genomic sequencing data from paired primary and metastatic tumours can be used to trace the evolutionary origins of cells responsible for metastasis. This approach has yielded new insights into the genomic alterations that engender metastatic potential, and the mechanisms by which cancer spreads. Given that the reliability of these approaches is contingent upon how representative the samples are of primary and metastatic tumour heterogeneity, we review insights from studies that have reconstructed the evolution of metastasis within the context of their cohorts and designs. We discuss the role of research autopsies in achieving the comprehensive sampling necessary to advance the current understanding of metastasis.

Type: Article
Title: Insights into the metastatic cascade through research autopsies
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.trecan.2023.03.002
Publisher version: https://doi.org/10.1016/j.trecan.2023.03.002
Language: English
Additional information: © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: genomic sequencing, metastasis, research autopsy, tumour evolution
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10168466
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