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Minimally invasive endoscopic therapies for gastro-oesophageal reflux disease

Aslam, N; Telese, A; Sehgal, V; Sweis, R; Lovat, LB; Haidry, R; (2023) Minimally invasive endoscopic therapies for gastro-oesophageal reflux disease. Frontline Gastroenterology , 14 (3) pp. 249-257. 10.1136/flgastro-2022-102343. Green open access

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Abstract

The prevalence of the gastro-oesophageal reflux disease (GORD) in the western world is increasing. Uncontrolled GORD can lead to harmful long-term sequela such as oesophagitis, stricture formation, Barrett's oesophagus and oesophageal adenocarcinoma. Moreover, GORD has been shown to negatively impact quality of life. The current treatment paradigm for GORD consists of lifestyle modification, pharmacological control of gastric acid secretion or antireflux surgery. In recent years, several minimally invasive antireflux endoscopic therapies (ARET) have been developed which may play a role in bridging the unmet therapeutic gap between the medical and surgical treatment options. To ensure optimal patient outcomes following ARET, considered patient selection is crucial, which requires a mechanistic understanding of individual ARET options. Here, we will discuss the differences between ARETs along with an overview of the current evidence base. We also outline future research priorities that will help refine the future role of ARET.

Type: Article
Title: Minimally invasive endoscopic therapies for gastro-oesophageal reflux disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/flgastro-2022-102343
Publisher version: https://doi.org/10.1136/flgastro-2022-102343
Language: English
Additional information: Copyright © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. See: https://creativecommons.org/licenses/by-nc/4.0/
Keywords: Anti-reflux therapy, diagnostic and therapeutic endoscopy, endoscopy, gastroesophageal reflux disease, oesophageal reflux
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10168450
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