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Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England

Nafilyan, V; Bermingham, CR; Ward, IL; Morgan, J; Zaccardi, F; Khunti, K; Stanborough, J; ... Doidge, JC; + view all (2023) Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England. Nature communications , 14 (1) , Article 1541. 10.1038/s41467-023-36494-0. Green open access

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Abstract

Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data in England to assess the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality in young people (12 to 29 years) using a self-controlled case series design. Here, we show there is no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared to more than 12 weeks after any dose. However, we find an increase in cardiac death in women after a first dose of non mRNA vaccines. A positive SARS-CoV-2 test is associated with increased cardiac and all-cause mortality among people vaccinated or unvaccinated at time of testing.

Type: Article
Title: Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41467-023-36494-0
Publisher version: https://doi.org/10.1038/s41467-023-36494-0
Language: English
Additional information: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Humans, Female, Adolescent, COVID-19 Vaccines, SARS-CoV-2, COVID-19, England, Vaccination
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
URI: https://discovery.ucl.ac.uk/id/eprint/10168380
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