Chan, Edgar;
Gal, Ana-Marija;
Van Harskamp, Natasja;
Adams, Matthew E;
Brown, Martin M;
Werring, David J;
Cipolotti, Lisa;
(2023)
Long-term study of the cognitive profile of Moyamoya Disease in adults.
Journal of Stroke and Cerebrovascular Diseases
, 32
(6)
, Article 107064. 10.1016/j.jstrokecerebrovasdis.2023.107064.
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Abstract
Moyamoya Disease (MMD) is a rare cerebrovascular disorder which can have significant cognitive consequences. The aim of the current study was to describe comprehensively the domain-specific cognitive profile of adult patients with MMD and to assess whether this changes in the absence of recurrent stroke over long-term follow-up. Comprehensive neuropsychological assessment covering seven cognitive domains was conducted on 61 adult patients with MMD at baseline and then at up to 3 further time points during follow up (median=2.31, 4.87 and 7.12 years). Although 27 patients had had prior surgical revasculariation, none had surgery between neuropsychological assessments. Cognitive impairment was common. At baseline, impairment in executive functions was most frequent (57%), followed by performance IQ (36%), speed of information processing (31%) and visual memory (30%). We found that the neuropsychological profile remains broadly stable over long-term follow-up with no clear indication of improvement or significant decline. The pattern of impairment also did not differ depending on age of onset or whether there was a history of either prior stroke at presentation or revascularisation surgery at presentation.
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