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Clinical Benefits of Therapeutic Interventions Targeting Mitochondria in Parkinson’s Disease Patients

Ciocca, Matteo; Pizzamiglio, Chiara; (2023) Clinical Benefits of Therapeutic Interventions Targeting Mitochondria in Parkinson’s Disease Patients. CNS & Neurological Disorders - Drug Targets 10.2174/1871527322666230330122444. (In press). Green open access

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Abstract

Parkinson’s disease is the second most common neurodegenerative disease. Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson’s disease, and several treatments targeting mitochondria have been tested in these patients to delay disease progression and tackle disease symptoms. Herein, we review available data from randomised, double-blind clinical studies that have investigated the role of compounds targeting mitochondria in idiopathic Parkinson’s disease patients, with a view of providing patients and clinicians with a comprehensive and practical paper that can inform therapeutic interventions in this group of people. A total of 9 compounds have been tested in randomized clinical trials, but only exenatide has shown some promising neuroprotective and symptomatic effects. However, whether this evidence can be translated into daily clinical practice still needs to be confirmed. In conclusion, targeting mitochondrial dysfunction in Parkinson’s disease is a promising therapeutic approach, although only one compound has shown a positive effect on Parkinson’s disease progression and symptoms. New compounds have been investigated in animal models, and their efficacy needs to be confirmed in humans through robust, randomised, double-blind clinical trials.

Type: Article
Title: Clinical Benefits of Therapeutic Interventions Targeting Mitochondria in Parkinson’s Disease Patients
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/1871527322666230330122444
Publisher version: https://doi.org/10.2174/1871527322666230330122444
Language: English
Additional information: © 2023 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/legalcode).
Keywords: Parkinson’s disease, treatment, mitochondria, supplements, neuroprotection, oxidative stress
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10168160
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