Zhu, Geyunjian H;
Azharuddin, Mohammad;
Pramanik, Bapan;
Roberg, Karin;
Biswas, Sujoy Kumar;
D'arcy, Padraig;
Lu, Meng;
... Patra, Hirak K; + view all
(2023)
Feasibility of Coacervate-Like Nanostructure for Instant Drug Nanoformulation.
ACS Applied Materials & Interfaces
, 15
(14)
pp. 17485-17494.
10.1021/acsami.2c21586.
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Abstract
Despite the enormous advancements in nanomedicine research, a limited number of nanoformulations are available on the market, and few have been translated to clinics. An easily scalable, sustainable, and cost-effective manufacturing strategy and long-term stability for storage are crucial for successful translation. Here, we report a system and method to instantly formulate NF achieved with a nanoscale polyelectrolyte coacervate-like system, consisting of anionic pseudopeptide poly(l-lysine isophthalamide) derivatives, polyethylenimine, and doxorubicin (Dox) via simple "mix-and-go" addition of precursor solutions in seconds. The coacervate-like nanosystem shows enhanced intracellular delivery of Dox to patient-derived multidrug-resistant (MDR) cells in 3D tumor spheroids. The results demonstrate the feasibility of an instant drug formulation using a coacervate-like nanosystem. We envisage that this technique can be widely utilized in the nanomedicine field to bypass the special requirement of large-scale production and elongated shelf life of nanomaterials.
| Type: | Article |
|---|---|
| Title: | Feasibility of Coacervate-Like Nanostructure for Instant Drug Nanoformulation |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsami.2c21586 |
| Publisher version: | https://doi.org/10.1021/acsami.2c21586 |
| Language: | English |
| Additional information: | Copyright © The Author 2023. This article is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | 3D tumor spheroids, coacervate-like nanostructure, instant nanoformulations, nanomedicine, self-assembly |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10167782 |
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