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Feasibility of Coacervate-Like Nanostructure for Instant Drug Nanoformulation

Zhu, Geyunjian H; Azharuddin, Mohammad; Pramanik, Bapan; Roberg, Karin; Biswas, Sujoy Kumar; D'arcy, Padraig; Lu, Meng; ... Patra, Hirak K; + view all (2023) Feasibility of Coacervate-Like Nanostructure for Instant Drug Nanoformulation. ACS Applied Materials & Interfaces , 15 (14) pp. 17485-17494. 10.1021/acsami.2c21586. Green open access

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Abstract

Despite the enormous advancements in nanomedicine research, a limited number of nanoformulations are available on the market, and few have been translated to clinics. An easily scalable, sustainable, and cost-effective manufacturing strategy and long-term stability for storage are crucial for successful translation. Here, we report a system and method to instantly formulate NF achieved with a nanoscale polyelectrolyte coacervate-like system, consisting of anionic pseudopeptide poly(l-lysine isophthalamide) derivatives, polyethylenimine, and doxorubicin (Dox) via simple "mix-and-go" addition of precursor solutions in seconds. The coacervate-like nanosystem shows enhanced intracellular delivery of Dox to patient-derived multidrug-resistant (MDR) cells in 3D tumor spheroids. The results demonstrate the feasibility of an instant drug formulation using a coacervate-like nanosystem. We envisage that this technique can be widely utilized in the nanomedicine field to bypass the special requirement of large-scale production and elongated shelf life of nanomaterials.

Type: Article
Title: Feasibility of Coacervate-Like Nanostructure for Instant Drug Nanoformulation
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsami.2c21586
Publisher version: https://doi.org/10.1021/acsami.2c21586
Language: English
Additional information: Copyright © The Author 2023. This article is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/).
Keywords: 3D tumor spheroids, coacervate-like nanostructure, instant nanoformulations, nanomedicine, self-assembly
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10167782
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