Zhao, Fei;
Zhang, Dengyou;
Nian, Yong;
Zhang, Lei;
Yang, Wei;
Liu, Hong;
(2014)
Palladium-Catalyzed Difunctionalization of Alkynes via C–N and S–N Cleavages: A Versatile Approach to Highly Functional Indoles.
Organic Letters
, 16
(19)
pp. 5124-5127.
10.1021/ol5024745.
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Abstract
Palladium-catalyzed intramolecular addition of C–N and S–N bond to alkynes with the migration of functional groups has been achieved. A wide range of functional groups including acyl, pyruvoyl, amide, and sulfonyl groups can migrate smoothly and be conveniently introduced at the C-3 postion of indoles in our catalytic system. The operational simplicity and broad substrate scope demonstrate the great potential of this method for the synthesis of highly functional indoles.
| Type: | Article |
|---|---|
| Title: | Palladium-Catalyzed Difunctionalization of Alkynes via C–N and S–N Cleavages: A Versatile Approach to Highly Functional Indoles |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/ol5024745 |
| Publisher version: | https://doi.org/10.1021/ol5024745 |
| Language: | English |
| Additional information: | This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10167673 |
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