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Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A

Filonenko, V; Gout, I; (2023) Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A. BBA Advances , 3 , Article 100075. 10.1016/j.bbadva.2023.100075. Green open access

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Abstract

Coenzyme A (CoA) is an essential cofactor in all living cells which plays critical role in cellular metabolism, the regulation of gene expression and the biosynthesis of major cellular constituents. Recently, CoA was found to function as a major antioxidant in both prokaryotic and eukaryotic cells. This unconventional function of CoA is mediated by a novel post-translational modification, termed protein CoAlation. This review will highlight the history of this discovery, current knowledge, and future directions on studying molecular mechanisms of protein CoAlation and whether the antioxidant function of CoA is associated with pathologies, such as neurodegeneration and cancer.

Type: Article
Title: Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbadva.2023.100075
Publisher version: https://doi.org/10.1016/j.bbadva.2023.100075
Language: English
Additional information: © 2023 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Reactive oxygen species; Redox regulation; Coenzyme A; Antioxidant function; Post-translational modification; Protein protein CoAlation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10167654
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