Filonenko, V;
Gout, I;
(2023)
Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A.
BBA Advances
, 3
, Article 100075. 10.1016/j.bbadva.2023.100075.
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Abstract
Coenzyme A (CoA) is an essential cofactor in all living cells which plays critical role in cellular metabolism, the regulation of gene expression and the biosynthesis of major cellular constituents. Recently, CoA was found to function as a major antioxidant in both prokaryotic and eukaryotic cells. This unconventional function of CoA is mediated by a novel post-translational modification, termed protein CoAlation. This review will highlight the history of this discovery, current knowledge, and future directions on studying molecular mechanisms of protein CoAlation and whether the antioxidant function of CoA is associated with pathologies, such as neurodegeneration and cancer.
| Type: | Article |
|---|---|
| Title: | Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bbadva.2023.100075 |
| Publisher version: | https://doi.org/10.1016/j.bbadva.2023.100075 |
| Language: | English |
| Additional information: | © 2023 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Reactive oxygen species; Redox regulation; Coenzyme A; Antioxidant function; Post-translational modification; Protein protein CoAlation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10167654 |
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