Sodergren, SC; Johnson, CD; Gilbert, A; Darlington, AS; Cocks, K; Guren, MG; Rivin del Campo, E; ... Vassiliou, V; + view all Sodergren, SC; Johnson, CD; Gilbert, A; Darlington, AS; Cocks, K; Guren, MG; Rivin del Campo, E; Brannan, C; Christensen, P; Chu, W; Chung, H; Dennis, K; Desideri, I; Gilbert, DC; Glynne-Jones, R; Jefford, M; Johansson, M; Johnsson, A; Juul, T; Kardamakis, D; Lai-Kwon, J; McFarlane, V; Miguel, IMC; Nugent, K; Peters, F; Riechelmann, RP; Turhal, NS; Wong, S; Vassiliou, V; - view fewer (2023) International Validation of the EORTC QLQ-ANL27, a Field Study to Test the Anal Cancer-Specific Health-Related Quality-of-Life Questionnaire. International Journal of Radiation Oncology Biology Physics , 115 (5) pp. 1155-1164. 10.1016/j.ijrobp.2022.11.002.

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Preview	Text (Supplementary Table 1) Gilbert_Supplementary Table 1_Sociodemographic characteristics.pdf - Accepted Version Download (137kB) | Preview
Preview	Text (Supplementary Table 2) Gilbert_Supplementary Table 2. Clinical characteristics.pdf - Accepted Version Download (134kB) | Preview
Preview	Text (Supplementary Table 3) Gilbert_Supplementary Table 3_CFA.pdf - Accepted Version Download (102kB) | Preview
Preview	Text (Supplementary Table 4) Gilbert_Supplementary Table 4_Item distributions.pdf - Accepted Version Download (145kB) | Preview
Preview	Text (Supplementary Table 5) Gilbert_Supplementary Table 5_Inter-item correlations.pdf - Accepted Version Download (1MB) | Preview

Abstract

Purpose: The European Organisation for Research and Treatment of Cancer (EORTC) health-related quality of life questionnaire for anal cancer (QLQ-ANL27) supplements the EORTC cancer generic measure (QLQ-C30) to measure concerns specific to people with anal cancer treated with chemoradiotherapy. This study tested the psychometric properties and acceptability of the QLQ-ANL27. Methods and / Materials: People with anal cancer were recruited from 15 countries to complete the QLQ-C30 and QLQ-ANL27 and provide feedback on the QLQ-ANL27. Item responses, scale structure (multitrait scaling, factor analysis), reliability (internal consistency and reproducibility) and sensitivity (known group comparisons and responsiveness to change) of the QLQ-ANL27 were evaluated. / Results: Data from 382 people were included in the analyses. The EORTC QLQ-ANL27 was acceptable, comprehensive, and easy to complete, taking an average 8 minutes to complete. Psychometric analyses supported the EORTC QLQ-ANL27 items and reliability (Cronbach's α ranging from 0.71-0.93 and test-retest coefficients above 0.7) and validity of the scales (particularly nonstoma bowel symptoms and pain/discomfort). Most scales distinguished people according to treatment phase and performance status. Bowel (nonstoma), pain/discomfort, and vaginal symptoms were sensitive to deteriorations over time. The stoma-related scales remained untested because of low numbers of people with a stoma. Revisions to the scoring and question ordering of the sexual items were proposed. / Conclusions: The QLQ-ANL27 has good psychometric properties and is available in 16 languages for people treated with chemoradiotherapy for anal cancer. It is used in clinical trials and has a potential role in clinical practice.

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