UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

Calvisi, DF; Boulter, L; Vaquero, J; Saborowski, A; Fabris, L; Rodrigues, PM; Coulouarn, C; ... Saito, Y; + view all (2023) Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance. Nature Reviews Gastroenterology and Hepatology , 20 pp. 462-480. 10.1038/s41575-022-00739-y. Green open access

[thumbnail of Bridgewater_221115_LF. Fouassier_V2_edited_CLEAN_1668185622_1MV.pdf]
Preview
Text
Bridgewater_221115_LF. Fouassier_V2_edited_CLEAN_1668185622_1MV.pdf

Download (674kB) | Preview

Abstract

Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains challenging, and effective treatments are lacking. Therefore, preclinical research is of pivotal importance and necessary to acquire a deeper understanding of CCA and improve therapeutic outcomes. Preclinical research involves developing and managing complementary experimental models, from in vitro assays using primary cells or cell lines cultured in 2D or 3D to in vivo models with engrafted material, chemically induced CCA or genetically engineered models. All are valuable tools with well-defined advantages and limitations. The choice of a preclinical model is guided by the question(s) to be addressed; ideally, results should be recapitulated in independent approaches. In this Consensus Statement, a task force of 45 experts in CCA molecular and cellular biology and clinicians, including pathologists, from ten countries provides recommendations on the minimal criteria for preclinical models to provide a uniform approach. These recommendations are based on two rounds of questionnaires completed by 35 (first round) and 45 (second round) experts to reach a consensus with 13 statements. An agreement was defined when at least 90% of the participants voting anonymously agreed with a statement. The ultimate goal was to transfer basic laboratory research to the clinics through increased disease understanding and to develop clinical biomarkers and innovative therapies for patients with CCA.

Type: Article
Title: Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41575-022-00739-y
Publisher version: https://doi.org/10.1038/s41575-022-00739-y
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: CCA Model Consortium
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10166641
Downloads since deposit
9Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item