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When to update COVID-19 vaccine composition

Grant, Rebecca; Sacks, Jilian A; Abraham, Priya; Chunsuttiwat, Supamit; Cohen, Cheryl; Figueroa, J Peter; Fleming, Thomas; ... Subbarao, Kanta; + view all (2023) When to update COVID-19 vaccine composition. Nature Medicine , 29 pp. 776-780. 10.1038/s41591-023-02220-y. Green open access

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Abstract

Entering the fourth year of the COVID-19 pandemic, index virus-based vaccines across several different platforms continue to provide high levels of protection against severe disease caused by all variants of SARS-CoV-2, including Omicron. However, there has been continuous and substantial evolution of SARS-CoV-2 since the virus emerged, posing challenges to the ongoing public health response, including ensuring that vaccines continue to provide protection. In September 2021, the World Health Organization (WHO) established the Technical Advisory Group on COVID-19 Vaccine Composition (TAG-CO-VAC)3 to assess the public health implications of emerging SARS-CoV-2 variants of concern (VOC) on the performance of COVID-19 vaccines and to issue timely recommendations on proposed modifications to vaccine antigen composition. The TAG-CO-VAC has evaluated evidence to inform its advice on COVID-19 vaccine composition so far, but there remain challenges and evidence gaps that the scientific community needs to address to enable future, timely decisions on modifications to COVID-19 vaccine antigen composition.

Type: Article
Title: When to update COVID-19 vaccine composition
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41591-023-02220-y
Publisher version: https://doi.org/10.1038/s41591-023-02220-y
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10166493
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