Daratumumab in AL amyloidosis

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Daratumumab in AL amyloidosis

Wechalekar, AD; Sanchorawala, V; (2022) Daratumumab in AL amyloidosis. Blood , 140 (22) pp. 2317-2322. 10.1182/blood.2021014613. Green open access

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Abstract

Light-chain amyloidosis has come far, with the first treatment getting regulatory approval in 2021. Daratumumab-based regimens achieve deep hematologic and organ responses, offering a new therapeutic backbone. Early identification, correct fibril typing, challenges of the very advanced patient, and lack of therapies to remove amyloid deposits remain under study, but are, as yet, elusive. We review the progress of treatment in AL amyloidosis, the impact of daratumumab, and the next steps after treatment.

Type:	Article
Title:	Daratumumab in AL amyloidosis
Location:	United States
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1182/blood.2021014613
Publisher version:	https://doi.org/10.1182/blood.2021014613
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	Humans, Immunoglobulin Light-chain Amyloidosis, Antibodies, Monoclonal, Amyloidosis
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI:	https://discovery.ucl.ac.uk/id/eprint/10166043

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