Trevelyan, Andrew J;
Graham, Robert T;
Parrish, R Ryley;
Codadu, Neela K;
(2022)
Synergistic Positive Feedback Mechanisms Underlying Seizure Initiation.
Epilepsy Currents
10.1177/15357597221127163.
(In press).
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Abstract
Investigations into seizure initiation, in recent years, have focused almost entirely upon alterations of interneuronal function, chloride homeostasis, and extracellular potassium levels. In contrast, little attention has been directed toward a possible role of dendritic plateau potentials in the actual ictogenic transition, despite a substantial literature dating back 40 years regarding its importance generally in epilepsy. Here, we argue that an increase in dendritic excitability, coordinated across the population of pyramidal cells, is a key stage in ictogenesis.
| Type: | Article |
|---|---|
| Title: | Synergistic Positive Feedback Mechanisms Underlying Seizure Initiation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/15357597221127163 |
| Publisher version: | https://doi.org/10.1177/15357597221127163 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | Pyramidal cell, dendritic plateau potential, inhibition, chloride, potassium, ictogenesis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10165856 |
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