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Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor

Delbridge, JN; Barrett, TA; Ducci, A; Micheletti, M; (2023) Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor. Chemical Engineering Science , 271 , Article 118545. 10.1016/j.ces.2023.118545. Green open access

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Abstract

The development of new biopharmaceuticals relies on robust scale-up from small-scale screening studies to industrial bioreactors. Novel SUB designs can prove highly beneficial, although they lack the extensive characterisation of traditional STRs. Pall Corporation's Allegro™ STR 50–2000 L bioreactor range has a unique design of square cross-section, with three wedge-shaped baffles. A scale-down 1 L prototype (abbreviated A-STR) was developed for characterisation studies and compared to a standard cylindrical STR (abbreviated S-STR). Agreement of power and mixing number data with that of the Allegro STR 200 L indicated successful scale-down. In down-pumping mode, mixing times in the A-STR were approximately 53 % lower than in the S-STR. However, in up-pumping mode both configurations exhibited similar mixing times. This study utilises a scale-down prototype to provide quantitative data on the commercial Allegro STR bioreactor range, to define operating parameters for enhanced scalability, and for comparison with a standard bioreactor geometry.

Type: Article
Title: Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ces.2023.118545
Publisher version: https://doi.org/10.1016/j.ces.2023.118545
Language: English
Additional information: © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Elephant Ear impeller, Mixing, Single-use, Scale-down, Asymmetric vessel, Irregular baffle
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10165784
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