Delbridge, JN;
Barrett, TA;
Ducci, A;
Micheletti, M;
(2023)
Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor.
Chemical Engineering Science
, 271
, Article 118545. 10.1016/j.ces.2023.118545.
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Abstract
The development of new biopharmaceuticals relies on robust scale-up from small-scale screening studies to industrial bioreactors. Novel SUB designs can prove highly beneficial, although they lack the extensive characterisation of traditional STRs. Pall Corporation's Allegro™ STR 50–2000 L bioreactor range has a unique design of square cross-section, with three wedge-shaped baffles. A scale-down 1 L prototype (abbreviated A-STR) was developed for characterisation studies and compared to a standard cylindrical STR (abbreviated S-STR). Agreement of power and mixing number data with that of the Allegro STR 200 L indicated successful scale-down. In down-pumping mode, mixing times in the A-STR were approximately 53 % lower than in the S-STR. However, in up-pumping mode both configurations exhibited similar mixing times. This study utilises a scale-down prototype to provide quantitative data on the commercial Allegro STR bioreactor range, to define operating parameters for enhanced scalability, and for comparison with a standard bioreactor geometry.
| Type: | Article |
|---|---|
| Title: | Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ces.2023.118545 |
| Publisher version: | https://doi.org/10.1016/j.ces.2023.118545 |
| Language: | English |
| Additional information: | © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Elephant Ear impeller, Mixing, Single-use, Scale-down, Asymmetric vessel, Irregular baffle |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10165784 |
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