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In Vivo N-Methyl-d-Aspartate Receptor (NMDAR) Density as Assessed Using Positron Emission Tomography During Recovery From NMDAR-Antibody Encephalitis

Galovic, M; Al-Diwani, A; Vivekananda, U; Walker, MC; Irani, SR; Koepp, MJ; (2023) In Vivo N-Methyl-d-Aspartate Receptor (NMDAR) Density as Assessed Using Positron Emission Tomography During Recovery From NMDAR-Antibody Encephalitis. JAMA Neurology , 80 (2) pp. 211-213. 10.1001/jamaneurol.2022.4352. Green open access

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Abstract

N-methyl-d-aspartate receptor (NMDAR) autoantibodies are a common cause of autoimmune encephalitis. In vitro and animal studies indicated that NMDAR internalization is a major mechanism underlying NMDAR-antibody encephalitis, but direct support in humans is limited to a reduction of NMDAR staining in postmortem hippocampi.

Type: Article
Title: In Vivo N-Methyl-d-Aspartate Receptor (NMDAR) Density as Assessed Using Positron Emission Tomography During Recovery From NMDAR-Antibody Encephalitis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1001/jamaneurol.2022.4352
Publisher version: http://doi.org/10.1001/jamaneurol.2022.4352
Language: English
Additional information: This version is the author accepted manuscript. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript (AAM) version arising from this submission
Keywords: Humans, Receptors, N-Methyl-D-Aspartate, Positron-Emission Tomography, Encephalitis, Autoantibodies, Anti-N-Methyl-D-Aspartate Receptor Encephalitis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10165660
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