Santana, Magda M;
Gaspar, Laetitia S;
Pinto, Maria M;
Silva, Patrick;
Adão, Diana;
Pereira, Dina;
Ribeiro, Joana Afonso;
... de Almeida, Luís Pereira; + view all
(2023)
A standardized protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia.
Neuropathology and Applied Neurobiology
, 49
(2)
, Article e12892. 10.1111/nan.12892.
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Abstract
The European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI) is a consortium established with the ambition to set up the largest European longitudinal trial-ready cohort of Spinocerebellar Ataxia Type 3/Machado Joseph disease (SCA3/MJD), the most common autosomal dominantly inherited ataxia worldwide. A major focus of ESMI has been the identification of SCA3/MJD biomarkers to enable future interventional studies. As biosample collection and processing variables significantly impact the outcomes of biomarkers studies, biosampling procedures standardization was done previously to study visit initiation. Here, we describe the ESMI consensus biosampling protocol, developed within the scope of ESMI, that ultimately might be translated to other neurodegenerative disorders, particularly ataxias, being the first step to protocol harmonization in the field.
| Type: | Article |
|---|---|
| Title: | A standardized protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/nan.12892 |
| Publisher version: | https://doi.org/10.1111/nan.12892 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors.. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Ataxia, Biomarkers, Blood, Cerebrospinal fluid, Neurodegenerative diseases, Protocol, Research, Standardization |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10165488 |
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