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Ageing changes in retinal outer nuclear layer thickness and cone photoreceptor density using adaptive optics-free imaging

Matlach, Juliane; Mulholland, Padraig; Cilkova, Marketa; Chopra, Reena; Shah, Nilpa; Redmond, Tony; Dakin, Steven C; ... Anderson, Roger S; + view all (2023) Ageing changes in retinal outer nuclear layer thickness and cone photoreceptor density using adaptive optics-free imaging. European Journal of Ophthalmology 10.1177/11206721221144477. (In press). Green open access

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Abstract

Purpose: To investigate age-related changes of the outer nuclear layer (ONL) thickness and cone density, and their associations in healthy participants using a modified, narrow scan-angle Heidelberg Retina Angiograph (HRA2). Methods: Retinal cones were imaged outside the fovea at 8.8° eccentricity and cone density was compared to ONL thickness measurements obtained by Spectral-Domain Optical Coherence Tomography (SD-OCT) at the same locations. Fifty-six eyes of 56 healthy participants with a median age (interquartile range, IQR) of 37 years (29–55) were included. Results: Median (IQR) cone count was 7,472 (7,188, 7,746) cones/mm2 and median (IQR) ONL thickness was 56 (52, 60) µm for healthy participants. Both cone density and ONL thickness were negatively associated with age: cone density, R2 = 0.16 (F(1,54) = 10.41, P = 0.002); ONL thickness, R2 = 0.12 (F(1,54) = 7.41, P = 0.009). No significant association was seen between cone density and ONL thickness (R2 = 0.03; F(1,54) = 1.66, P = 0.20). Conclusion: Cone density was lower, and ONL thinner, in older compared to younger participants, therefore, image-based structural measures should be compared to age-related data. However, cone density and ONL thickness were not strongly associated, indicating that determinants of ONL thickness measurements other than cone density measurements, and including measurement error, have a major influence.

Type: Article
Title: Ageing changes in retinal outer nuclear layer thickness and cone photoreceptor density using adaptive optics-free imaging
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/11206721221144477
Publisher version: https://doi.org/10.1177/11206721221144477
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cone imaging, imaging, Life Sciences & Biomedicine, OCT, Ophthalmology, outer nuclear layer, PACKING DENSITY, RETINITIS-PIGMENTOSA, Science & Technology, WIDE
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10165481
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