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Hepatic encephalopathy

Häussinger, D; Dhiman, RK; Felipo, V; Görg, B; Jalan, R; Kircheis, G; Merli, M; ... Vilstrup, H; + view all (2022) Hepatic encephalopathy. Nature Reviews Disease Primers , 8 (1) , Article 43. 10.1038/s41572-022-00366-6. Green open access

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Abstract

Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that occurs in the course of acute or chronic liver disease. Besides ascites and variceal bleeding, it is the most serious complication of decompensated liver cirrhosis. Ammonia and inflammation are major triggers for the appearance of HE, which in patients with liver cirrhosis involves pathophysiologically low-grade cerebral oedema with oxidative/nitrosative stress, inflammation and disturbances of oscillatory networks in the brain. Severity classification and diagnostic approaches regarding mild forms of HE are still a matter of debate. Current medical treatment predominantly involves lactulose and rifaximin following rigorous treatment of so-called known HE precipitating factors. New treatments based on an improved pathophysiological understanding are emerging.

Type: Article
Title: Hepatic encephalopathy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41572-022-00366-6
Publisher version: https://doi.org/10.1038/s41572-022-00366-6
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Encephalopathy, Liver cirrhosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10165340
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