Godoy-Corchuelo, Juan Miguel;
Fernandez-Beltran, Luis C;
Ali, Zeinab;
Gil-Moreno, Maria J;
Lopez-Carbonero, Juan I;
Guerrero-Sola, Antonio;
Larrad-Sainz, Angelica;
... Corrochano, Silvia; + view all
(2022)
Lipid Metabolic Alterations in the ALS-FTD Spectrum of Disorders.
Biomedicines
, 10
(5)
, Article 1105. 10.3390/biomedicines10051105.
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Abstract
There is an increasing interest in the study of the relation between alterations in systemic lipid metabolism and neurodegenerative disorders, in particular in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). In ALS these alterations are well described and evident not only with the progression of the disease but also years before diagnosis. Still, there are some discrepancies in findings relating to the causal nature of lipid metabolic alterations, partly due to the great clinical heterogeneity in ALS. ALS presentation is within a disorder spectrum with Frontotem-poral Dementia (FTD), and many patients present mixed forms of ALS and FTD, thus increasing the variability. Lipid metabolic and other systemic metabolic alterations have not been well studied in FTD, or in ALS–FTD mixed forms, as has been in pure ALS. With the recent development in lipidomics and the integration with other-omics platforms, there is now emerging data that not only facilitates the identification of biomarkers but also enables understanding of the underlying pathological mechanisms. Here, we reviewed the recent literature to compile lipid metabolic alterations in ALS, FTD, and intermediate mixed forms, with a view to appraising key commonalities or differences within the spectrum.
| Type: | Article |
|---|---|
| Title: | Lipid Metabolic Alterations in the ALS-FTD Spectrum of Disorders |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/biomedicines10051105 |
| Publisher version: | https://doi.org/10.3390/biomedicines10051105 |
| Language: | English |
| Additional information: | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Medicine, Research & Experimental, Pharmacology & Pharmacy, Research & Experimental Medicine, lipid metabolism, ALS, FTD, lipidomics, cholesterol, AMYOTROPHIC-LATERAL-SCLEROSIS, BODY-MASS INDEX, FRONTOTEMPORAL LOBAR DEGENERATION, HEXANUCLEOTIDE REPEAT, DISEASE PATHOGENESIS, CHOLESTEROL, SURVIVAL, DEATH, ACID, FAT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases > MRC Prion Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10165276 |
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