de Jong, Jody M;
Broekaart, Diede WM;
Bongaarts, Anika;
Muhlebner, Angelika;
Mills, James D;
van Vliet, Erwin A;
Aronica, Eleonora;
(2022)
Altered Extracellular Matrix as an Alternative Risk Factor for Epileptogenicity in Brain Tumors.
Biomedicines
, 10
(10)
, Article 2475. 10.3390/biomedicines10102475.
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Abstract
Seizures are one of the most common symptoms of brain tumors. The incidence of seizures differs among brain tumor type, grade, location and size, but paediatric-type diffuse low-grade gliomas/glioneuronal tumors are often highly epileptogenic. The extracellular matrix (ECM) is known to play a role in epileptogenesis and tumorigenesis because it is involved in the (re)modelling of neuronal connections and cell-cell signaling. In this review, we discuss the epileptogenicity of brain tumors with a focus on tumor type, location, genetics and the role of the extracellular matrix. In addition to functional problems, epileptogenic tumors can lead to increased morbidity and mortality, stigmatization and life-long care. The health advantages can be major if the epileptogenic properties of brain tumors are better understood. Surgical resection is the most common treatment of epilepsy-associated tumors, but post-surgery seizure-freedom is not always achieved. Therefore, we also discuss potential novel therapies aiming to restore ECM function.
| Type: | Article |
|---|---|
| Title: | Altered Extracellular Matrix as an Alternative Risk Factor for Epileptogenicity in Brain Tumors |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/biomedicines10102475 |
| Publisher version: | https://doi.org/10.3390/biomedicines10102475 |
| Language: | English |
| Additional information: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Medicine, Research & Experimental, Pharmacology & Pharmacy, Research & Experimental Medicine, brain tumor, extracellular matrix, matrix metalloproteinases, epileptogenesis, low-grade gliomas, low-grade epilepsy-associated neuroepithelial tumors, CENTRAL-NERVOUS-SYSTEM, CHONDROITIN SULFATE PROTEOGLYCANS, UROKINASE PLASMINOGEN-ACTIVATOR, DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS, HEALTH-ORGANIZATION CLASSIFICATION, TEMPORAL-LOBE EPILEPSY, LOW-GRADE GLIOMA, METALLOPROTEINASE ACTIVITY, PERINEURONAL NETS, HEPARAN-SULFATE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10165275 |
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