Murr, Martina;
Brock, Kristy K;
Fusella, Marco;
Hardcastle, Nicholas;
Hussein, Mohammad;
Jameson, Michael G;
Wahlstedt, Isak;
... Vasquez Osorio, Eliana; + view all
(2023)
Applicability and usage of dose mapping/accumulation in radiotherapy.
Radiotherapy and Oncology
, 182
, Article 109527. 10.1016/j.radonc.2023.109527.
Preview |
Text
McClelland_Applicability and usage of dose mapping_accumulation in radiotherapy_VoR.pdf Download (2MB) | Preview |
Abstract
Dose mapping/accumulation (DMA) is a topic in radiotherapy (RT) for years, but has not yet found its widespread way into clinical RT routine. During the ESTRO Physics workshop 2021 on "commissioning and quality assurance of deformable image registration (DIR) for current and future RT applications", we built a working group on DMA from which we present the results of our discussions in this article. Our aim in this manuscript is to shed light on the current situation of DMA in RT and to highlight the issues that hinder consciously integrating it into clinical RT routine. As a first outcome of our discussions, we present a scheme where representative RT use cases are positioned, considering expected anatomical variations and the impact of dose mapping uncertainties on patient safety, which we have named the DMA landscape (DMAL). This tool is useful for future reference when DMA applications get closer to clinical day-to-day use. Secondly, we discussed current challenges, lightly touching on first-order effects (related to the impact of DIR uncertainties in dose mapping), and focusing in detail on second-order effects often dismissed in the current literature (as resampling and interpolation, quality assurance considerations, and radiobiological issues). Finally, we developed recommendations, and guidelines for vendors and users. Our main point include: Strive for context-driven DIR (by considering their impact on clinical decisions/judgements) rather than perfect DIR; be conscious of the limitations of the implemented DIR algorithm; and consider when dose mapping (with properly quantified uncertainties) is a better alternative than no mapping.
| Type: | Article |
|---|---|
| Title: | Applicability and usage of dose mapping/accumulation in radiotherapy |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.radonc.2023.109527 |
| Publisher version: | https://doi.org/10.1016/j.radonc.2023.109527 |
| Language: | English |
| Additional information: | Copyright 2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | DIR uncertainties, anatomical changes, deformable image registration (DIR), dose accumulation, dose mapping, dose mapping/accumulation landscape (DMAL), impact of dose mapping uncertainties |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10165266 |
Archive Staff Only
 |
View Item |
