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Statistical Modelling of the Visual Impact of Subretinal Fluid and Associated Features

Aslam, Tariq M; Mahmood, Sajjad; Balaskas, Konstantinos; Hoyle, David C; (2021) Statistical Modelling of the Visual Impact of Subretinal Fluid and Associated Features. Ophthalmology and Therapy , 10 (1) pp. 127-135. 10.1007/s40123-020-00327-w. Green open access

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Abstract

Introduction: The aim of this study was to develop a statistical model to determine the visual significance of subretinal fluid (SRF) in combination with other constructed optical coherence tomography (OCT) features in patients with wet age-related macular degeneration. Methods: The project used labelled data from 1211 OCTs of patients with neovascular macular degeneration (nAMD) attending the macular treatment centre of Manchester Royal Eye Hospital to build a statistical model to determine vision for any virtual, constructed OCT. A four-dimensional plot was created to represent the visual impact of SRF in OCTs in the context of the associated OCT characteristics of atrophy and subretinal hyperreflective material (SHRM). Results: The plot illustrates that at levels of SRF below 150 µm, the impact of SRF on vision is very low. Increasing the amount of fluid to 200 µm and beyond increases the impact on vision, but only if there is little atrophy or SHRM. Conclusions: This study suggests that levels of SRF up to around 150 µm thickness on OCT have minimal impact on vision. Greater levels of SRF have greater impact on vision, unless associated with significant amounts of atrophy or SHRM, when the additional effect of the SRF on vision remains low.

Type: Article
Title: Statistical Modelling of the Visual Impact of Subretinal Fluid and Associated Features
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40123-020-00327-w
Publisher version: https://doi.org/10.1007/s40123-020-00327-w
Language: English
Additional information: © 2023 Springer Nature Switzerland AG. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/).
Keywords: Image analysis, Macular degeneration, Optical coherence tomography, Subretinal fluid
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10165122
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