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Tissue-specific targeting of DNA nanodevices in a multicellular living organism

Chakraborty, Kasturi; Anees, Palapuravan; Surana, Sunaina; Martin, Simona; Aburas, Jihad; Moutel, Sandrine; Perez, Franck; ... Krishnan, Yamuna; + view all (2021) Tissue-specific targeting of DNA nanodevices in a multicellular living organism. eLife , 10 , Article e67830. 10.7554/eLife.67830. Green open access

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Abstract

Nucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease targets that need corrective action are localized in specific organs and thus realizing the full potential of DNA nanodevices also requires ways to target them to specific cell-types in vivo. Here we show that by exploiting either endogenous or synthetic receptor-ligand interactions and by leveraging the biological barriers presented by the organism, we can target extraneously introduced DNA nanodevices to specific cell types in C. elegans, with sub-cellular precision. The amenability of DNA nanostructures to tissue-specific targeting in vivo significantly expands their utility in biomedical applications and discovery biology.

Type: Article
Title: Tissue-specific targeting of DNA nanodevices in a multicellular living organism
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.67830
Publisher version: https://doi.org/10.7554/eLife.67830
Language: English
Additional information: Copyright Chakraborty et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, FREE CLICK CHEMISTRY, DOUBLE-STRANDED-RNA, CAENORHABDITIS-ELEGANS, C-ELEGANS, ANTIBODY FRAGMENTS, GENE-EXPRESSION, PH CHANGES, PROTEIN, ACID, TRANSPORT
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10164955
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