UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Acute syphilitic necrotizing retinitis associated with placoid chorioretinitis in an immunocompetent patient

Kreps, Elke O; Jasim, Haneen; Mamtora, Sunil; Dick, Andrew D; (2022) Acute syphilitic necrotizing retinitis associated with placoid chorioretinitis in an immunocompetent patient. Retinal Cases & Brief Reports 10.1097/ICB.0000000000001361. (In press). Green open access

[thumbnail of Accepted Manuscript]
Preview
Text (Accepted Manuscript)
Dick_Acute syphilitic necrotizing retinitis associated with placoid chorioretinitis in an immunocompetent patient_AAM.pdf

Download (60kB) | Preview
[thumbnail of Figure_1.jpg]
Preview
Image
Figure_1.jpg - Accepted Version

Download (1MB) | Preview

Abstract

PURPOSE: We report an atypical case of combined acute syphilitic necrotizing retinitis and a contiguous acute syphilitic posterior placoid chorioretinitis (ASPPC) in an HIV-negative, immunocompetent patient. METHOD: Observational case report. RESULTS: A 56-year-old male presented with a one-week history of pain and blurred vision in the left eye. He also complained of left-sided hearing loss for several months. Ocular examination demonstrated a unilateral panuveitis with a yellowish placoid macular lesion involving the outer retina contiguous with an ovoid area of full-thickness retinitis extending temporally. Vitreal polymerase chain reaction (PCR) analysis for HSV, CMV, VZV and T. gondii were negative but syphilis serology was reported as positive. An MRI of the head revealed bilateral enhancement along the facial nerves, more marked on the left side, consistent with syphilitic involvement. He was treated as neurosyphilis with a 14-day course of systemic procaine penicillin and oral probenecid. Oral prednisolone (1 mg/kg/day) was commenced 24 hours prior to initiating antibiotics to prevent Jarisch-Herxheimer reaction and treat his panuveitis. CONCLUSION: To our knowledge, this is the first report of combined syphilitic necrotizing retinitis and ASPPC occurring in continuity in the same eye. This case highlights the diversity of possible presentations of ocular syphilis, even in HIV-negative immunocompetent patients.

Type: Article
Title: Acute syphilitic necrotizing retinitis associated with placoid chorioretinitis in an immunocompetent patient
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/ICB.0000000000001361
Publisher version: https://doi.org/10.1097/ICB.0000000000001361
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10164932
Downloads since deposit
15Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item