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Generative models of morphogenesis in developmental biology

Stillman, Namid R; Mayor, Roberto; (2023) Generative models of morphogenesis in developmental biology. Seminars in Cell & Developmental Biology 10.1016/j.semcdb.2023.02.001. (In press). Green open access

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Abstract

Understanding the mechanism by which cells coordinate their differentiation and migration is critical to our understanding of many fundamental processes such as wound healing, disease progression, and developmental biology. Mathematical models have been an essential tool for testing and developing our understanding, such as models of cells as soft spherical particles, reaction-diffusion systems that couple cell movement to environmental factors, and multi-scale multi-physics simulations that combine bottom-up rule-based models with continuum laws. However, mathematical models can often be loosely related to data or have so many parameters that model behaviour is weakly constrained. Recent methods in machine learning introduce new means by which models can be derived and deployed. In this review, we discuss examples of mathematical models of aspects of developmental biology, such as cell migration, and how these models can be combined with these recent machine learning methods.

Type: Article
Title: Generative models of morphogenesis in developmental biology
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.semcdb.2023.02.001
Publisher version: https://doi.org/10.1016/j.semcdb.2023.02.001
Language: English
Additional information: © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Cell migration, Computational biology, Developmental biology, Generative models, Simulation-based inference
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10164905
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