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The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens)

Zhang, Wanchang; Wang, Hongru; Brandt, Débora YC; Hu, Beijuan; Sheng, Junqing; Wang, Mengnan; Luo, Haijiang; ... Hong, Yijiang; + view all (2022) The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens). Science Advances , 8 (38) , Article eabm4955. 10.1126/sciadv.abm4955. Green open access

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Abstract

The Betta fish displays a remarkable variety of phenotypes selected during domestication. However, the genetic basis underlying these traits remains largely unexplored. Here, we report a high-quality genome assembly and resequencing of 727 individuals representing diverse morphotypes of the Betta fish. We show that current breeds have a complex domestication history with extensive introgression with wild species. Using a genome-wide association study, we identify the genetic basis of multiple traits, including coloration patterns, the "Dumbo" phenotype with pectoral fin outgrowth, extraordinary enlargement of body size that we map to a major locus on chromosome 8, the sex determination locus that we map to dmrt1, and the long-fin phenotype that maps to the locus containing kcnj15. We also identify a polygenic signal related to aggression, involving multiple neural system-related genes such as esyt2, apbb2, and pank2. Our study provides a resource for developing the Betta fish as a genetic model for morphological and behavioral research in vertebrates.

Type: Article
Title: The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens)
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/sciadv.abm4955
Publisher version: https://doi.org/10.1126/sciadv.abm4955
Language: English
Additional information: Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Keywords: Aggression, Animals, Fishes, Genome-Wide Association Study, Phenotype, Sequence Analysis, DNA
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10164886
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