Milton, AL;
Das, RK;
Merlo, E;
(2023)
The challenge of memory destabilisation: From prediction error to prior expectations and biomarkers.
Brain Research Bulletin
, 194
pp. 100-104.
10.1016/j.brainresbull.2023.01.010.
(In press).
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Abstract
The re-ignition of memory reconsolidation research sparked by Karim Nader in the early 2000s led to great excitement that ‘reconsolidation-based’ interventions might be developed for mental health disorders such as post-traumatic stress disorder and substance use disorder. Two decades on, it is clear that reconsolidation-based interventions have been more challenging to translate to the clinic than initially thought. We argue that this challenge could be addressed with a better understanding of how prior expectations interact with information presented in a putative memory reactivation / cue reminder session, and through the identification of non-invasive biomarkers for memory destabilisation that would allow reminder sessions to be ‘tuned’ to enhance memory lability in an ad hoc manner.
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