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Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

Nagelkerke, Anika; Ojansivu, Miina; van der Koog, Luke; Whittaker, Thomas E; Cunnane, Eoghan M; Silva, Andreia M; Dekker, Niek; (2021) Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities. Advanced Drug Delivery Reviews , 175 , Article 113775. 10.1016/j.addr.2021.04.013. Green open access

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Abstract

Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety of diseases and conditions. In this review paper, we report on the potential of EVs in tissue repair and regeneration. The regenerative properties that have been associated with EVs are explored, detailing the molecular cargo they carry that is capable of mediating such effects, the signaling cascades triggered in target cells and the functional outcome achieved. EV interactions and biodistribution in vivo that influence their regenerative effects are also described, particularly upon administration in combination with biomaterials. Finally, we review the progress that has been made for the successful implementation of EV regenerative therapies in a clinical setting.

Type: Article
Title: Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.addr.2021.04.013
Publisher version: https://doi.org/10.1016/j.addr.2021.04.013
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Regenerative medicine, Mesenchymal stem cells, Therapeutic cargo delivery, EV engineering, EV-functionalized biomaterials, Clinical trial,
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10164504
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