El-Dib, M;
Abend, NS;
Austin, T;
Boylan, G;
Chock, V;
Cilio, MR;
Greisen, G;
... McCaul, MC; + view all
(2022)
Neuromonitoring in neonatal critical care part I: neonatal encephalopathy and neonates with possible seizures.
Pediatric Research
10.1038/s41390-022-02393-1.
(In press).
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Abstract
Abstract: The blooming of neonatal neurocritical care over the last decade reflects substantial advances in neuromonitoring and neuroprotection. The most commonly used brain monitoring tools in the neonatal intensive care unit (NICU) are amplitude integrated EEG (aEEG), full multichannel continuous EEG (cEEG), and near-infrared spectroscopy (NIRS). While some published guidelines address individual tools, there is no consensus on consistent, efficient, and beneficial use of these modalities in common NICU scenarios. This work reviews current evidence to assist decision making for best utilization of neuromonitoring modalities in neonates with encephalopathy or with possible seizures. Neuromonitoring approaches in extremely premature and critically ill neonates are discussed separately in the companion paper. Impact: Neuromonitoring techniques hold promise for improving neonatal care.For neonatal encephalopathy, aEEG can assist in screening for eligibility for therapeutic hypothermia, though should not be used to exclude otherwise eligible neonates. Continuous cEEG, aEEG and NIRS through rewarming can assist in prognostication.For neonates with possible seizures, cEEG is the gold standard for detection and diagnosis. If not available, aEEG as a screening tool is superior to clinical assessment alone. The use of seizure detection algorithms can help with timely seizures detection at the bedside.
| Type: | Article |
|---|---|
| Title: | Neuromonitoring in neonatal critical care part I: neonatal encephalopathy and neonates with possible seizures |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41390-022-02393-1 |
| Publisher version: | https://doi.org/10.1038/s41390-022-02393-1 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Pediatrics, HYPOXIC-ISCHEMIC ENCEPHALOPATHY, AMPLITUDE-INTEGRATED ELECTROENCEPHALOGRAPHY, NEAR-INFRARED SPECTROSCOPY, CEREBRAL FUNCTION MONITOR, ELECTROGRAPHIC SEIZURES, THERAPEUTIC HYPOTHERMIA, PROGNOSTIC VALUE, CONVENTIONAL ELECTROENCEPHALOGRAPHY, TEMPORAL CHARACTERISTICS, SYSTEMIC HYPOTHERMIA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10164350 |
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