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Elucidating the mechanisms behind nucleogenesis of the avian auditory hindbrain: a focus on the nucleus Laminaris

Clark, Maryam; (2023) Elucidating the mechanisms behind nucleogenesis of the avian auditory hindbrain: a focus on the nucleus Laminaris. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Abstract

A major recurrent form of organisation in the vertebrate CNS are neuronal nuclei. During early brain development, neural cells are generated and undergo a complex journey of migration, adhesion and nucleus structural formation. Together, this process is known as nucleogenesis; a process whose governing mechanisms are still poorly understood. Nonetheless, failure to form stereotypical nuclei has been linked to heterotopia; a condition linked to multiple neurological disorders, including epilepsy, autism spectrum disorder, Van Maldergem syndrome, schizophrenia and more. This project utilises a number of interdisciplinary techniques to elucidate the genetic and physical mechanisms that aid in the development of the tertiary avian auditory nucleus, the nucleus Laminaris. A monolayered structure, this project suggests that cadherin-involved control of neural progenitor cell exit from the ventricular zone, neural cell shape and an autoregulatory signalling factor (FGF8), could be important factors in its formation. Further, an adapted slice culture technique and multiple demonstrations of its use present the future for further research into nucleogenesis of the nL.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Elucidating the mechanisms behind nucleogenesis of the avian auditory hindbrain: a focus on the nucleus Laminaris
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2023. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10164347
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