UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Annelid functional genomics reveal the origins of bilaterian life cycles

Martín-Zamora, Francisco M; Liang, Yan; Guynes, Kero; Carrillo-Baltodano, Allan M; Davies, Billie E; Donnellan, Rory D; Tan, Yongkai; ... Martín-Durán, José M; + view all (2023) Annelid functional genomics reveal the origins of bilaterian life cycles. Nature 10.1038/s41586-022-05636-7. (In press). Green open access

[thumbnail of Marletaz_Annelid functional genomics reveal the origins of bilaterian life cycles_AOP.pdf]
Preview
Text
Marletaz_Annelid functional genomics reveal the origins of bilaterian life cycles_AOP.pdf - Published Version

Download (50MB) | Preview

Abstract

Indirect development with an intermediate larva exists in all major animal lineages1, which makes larvae central to most scenarios of animal evolution2-11. Yet how larvae evolved remains disputed. Here we show that temporal shifts (that is, heterochronies) in trunk formation underpin the diversification of larvae and bilaterian life cycles. We performed chromosome-scale genome sequencing in the annelid Owenia fusiformis with transcriptomic and epigenomic profiling during the life cycles of this and two other annelids. We found that trunk development is deferred to pre-metamorphic stages in the feeding larva of O. fusiformis but starts after gastrulation in the non-feeding larva with gradual metamorphosis of Capitella teleta and the direct developing embryo of Dimorphilus gyrociliatus. Accordingly, the embryos of O. fusiformis develop first into an enlarged anterior domain that forms larval tissues and the adult head12. Notably, this also occurs in the so-called 'head larvae' of other bilaterians13-17, with which the O. fusiformis larva shows extensive transcriptomic similarities. Together, our findings suggest that the temporal decoupling of head and trunk formation, as maximally observed in head larvae, facilitated larval evolution in Bilateria. This diverges from prevailing scenarios that propose either co-option9,10 or innovation11 of gene regulatory programmes to explain larva and adult origins.

Type: Article
Title: Annelid functional genomics reveal the origins of bilaterian life cycles
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41586-022-05636-7
Publisher version: https://doi.org/10.1038/s41586-022-05636-7
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10164129
Downloads since deposit
149Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item