Guan, Qingwen;
He, Binbin;
Huang, Jie;
Lu, Helen H;
Wang, Min;
(2022)
Hybrid ceramics-based cancer theranostics.
Journal of the Korean Ceramic Society
, 59
pp. 401-426.
10.1007/s43207-022-00217-w.
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Abstract
Cancer is a major threat to human lives. Early detection and precisely targeted therapy/therapies for cancer is the most effective way to reduce the difficulties (e.g., side effects, low survival rate, etc.) in treating cancer. To enable effective cancer detection and treatment, ceramic biomaterials have been intensively and extensively investigated owing to their good biocompatibility, high bioactivity, suitable biodegradability and other distinctive properties that are required for medical devices in oncology. Through hybridization with other materials and loading of imaging agents and therapeutic agents, nanobioceramics can form multifunctional nanodevices to simultaneously provide diagnostic and therapeutic functions for cancer patients, and these nanodevices are known as hybrid ceramics-based cancer theranostics. In this review, the recent developments of hybrid ceramics-based cancer theranostics, which include the key aspects such as their preparation, biological evaluation and applications, are summarized and discussed. The challenges and future perspectives for the clinical translation of hybrid ceramics-based cancer theranostics are also discussed. It is believed that the potential of hybrid ceramic nanoparticles as cancer theranostics is high and that the future of these theranostics is bright despite the difficulties along the way for their clinical translation.
| Type: | Article |
|---|---|
| Title: | Hybrid ceramics-based cancer theranostics |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s43207-022-00217-w |
| Publisher version: | https://doi.org/10.1007/s43207-022-00217-w |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Technology, Materials Science, Ceramics, Materials Science, Cancer, Detection, Therapy, Theranostics, Multifunctional, Bioceramics, Calcium phosphate, Silica, Bioactive glass, Clinical, CALCIUM-PHOSPHATE NANOPARTICLES, MESOPOROUS SILICA NANOPARTICLES, DRUG-DELIVERY, IN-VITRO, BIOACTIVE GLASSES, IMPROVED DEGRADABILITY, MAGNETIC HYPERTHERMIA, PHOTOTHERMAL THERAPY, GENE-THERAPY, BONE-TUMORS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10164051 |
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