UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Development and validation of a multivariable risk factor questionnaire to detect oesophageal cancer in 2-week wait patients

Ho, Kai Man Alexander; Rosenfeld, Avi; Hogan, Áine; McBain, Hazel; Duku, Margaret; Wolfson, Paul Bd; Wilson, Ashley; ... Lovat, Laurence B; + view all (2023) Development and validation of a multivariable risk factor questionnaire to detect oesophageal cancer in 2-week wait patients. Clinics and Research in Hepatology and Gastroenterology , 47 (3) , Article 102087. 10.1016/j.clinre.2023.102087. Green open access

[thumbnail of Development and validation of a multivariable risk factor questionnaire to detect oesophageal cancer in 2-week wait patients.pdf]
Preview
Text
Development and validation of a multivariable risk factor questionnaire to detect oesophageal cancer in 2-week wait patients.pdf

Download (1MB) | Preview

Abstract

INTRODUCTION: Oesophageal cancer is associated with poor health outcomes. Upper GI (UGI) endoscopy is the gold standard for diagnosis but is associated with patient discomfort and low yield for cancer. We used a machine learning approach to create a model which predicted oesophageal cancer based on questionnaire responses. METHODS: We used data from 2 separate prospective cross-sectional studies: the Saliva to Predict rIsk of disease using Transcriptomics and epigenetics (SPIT) study and predicting RIsk of diSease using detailed Questionnaires (RISQ) study. We recruited patients from National Health Service (NHS) suspected cancer pathways as well as patients with known cancer. We identified patient characteristics and questionnaire responses which were most associated with the development of oesophageal cancer. Using the SPIT dataset, we trained seven different machine learning models, selecting the best area under the receiver operator curve (AUC) to create our final model. We further applied a cost function to maximise cancer detection. We then independently validated the model using the RISQ dataset. RESULTS: 807 patients were included in model training and testing, split in a 70:30 ratio. 294 patients were included in model validation. The best model during training was regularised logistic regression using 17 features (median AUC: 0.81, interquartile range (IQR): 0.69-0.85). For testing and validation datasets, the model achieved an AUC of 0.71 (95% CI: 0.61-0.81) and 0.92 (95% CI: 0.88-0.96) respectively. At a set cut off, our model achieved a sensitivity of 97.6% and specificity of 59.1%. We additionally piloted the model in 12 patients with gastric cancer; 9/12 (75%) of patients were correctly classified. CONCLUSIONS: We have developed and validated a risk stratification tool using a questionnaire approach. This could aid prioritising patients at high risk of having oesophageal cancer for endoscopy. Our tool could help address endoscopic backlogs caused by the COVID-19 pandemic.

Type: Article
Title: Development and validation of a multivariable risk factor questionnaire to detect oesophageal cancer in 2-week wait patients
Location: France
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.clinre.2023.102087
Publisher version: https://doi.org/10.1016/j.clinre.2023.102087
Language: English
Additional information: Copyright © 2023 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10164020
Downloads since deposit
90Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item