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Intra-operative OCT (iOCT) Super Resolution: A Two-Stage Methodology Leveraging High Quality Pre-operative OCT Scans

Komninos, C; Pissas, T; Flores, B; Bloch, E; Vercauteren, T; Ourselin, S; Cruz, LD; (2022) Intra-operative OCT (iOCT) Super Resolution: A Two-Stage Methodology Leveraging High Quality Pre-operative OCT Scans. In: Antony, B and Fu, H and Lee, CS and MacGillivray, T and Xu, Y and Zheng, Y, (eds.) International Workshop on Ophthalmic Medical Image Analysis OMIA 2022: Ophthalmic Medical Image Analysis. (pp. pp. 105-114). Springer, Cham Green open access

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Abstract

Regenerative therapies have recently shown potential in restoring sight lost due to degenerative diseases. Their efficacy requires precise intra-retinal delivery, which can be achieved by robotic systems accompanied by high quality visualization of retinal layers. Intra-operative Optical Coherence Tomography (iOCT) captures cross-sectional retinal images in real-time but with image quality that is inadequate for intra-retinal therapy delivery. This paper proposes a two-stage super-resolution methodology that enhances the image quality of the low resolution (LR) iOCT images leveraging information from pre-operatively acquired high-resolution (HR) OCT (preOCT) images. First, we learn the degradation process from HR to LR domain through CycleGAN and use it to generate pseudo iOCT (LR) images from the HR preOCT ones. Then, we train a Pix2Pix model on the pairs of pseudo iOCT and preOCT to learn the super-resolution mapping. Quantitative analysis using both full-reference and no-reference image quality metrics demonstrates that our approach clearly outperforms the learning-based state-of-the art techniques with statistical significance. Achieving iOCT image quality comparable to preOCT quality can help this medical imaging modality be established in vitreoretinal surgery, without requiring expensive hardware-related system updates.

Type: Proceedings paper
Title: Intra-operative OCT (iOCT) Super Resolution: A Two-Stage Methodology Leveraging High Quality Pre-operative OCT Scans
Event: Ophthalmic Medical Image Analysis 9th International Workshop, OMIA 2022, Held in Conjunction with MICCAI 2022
Location: Singapore, SINGAPORE
Dates: 22 Sep 2022
ISBN-13: 9783031165245
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-031-16525-2_11
Publisher version: https://doi.org/10.1007/978-3-031-16525-2_11
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Ophthalmology, Radiology, Nuclear Medicine & Medical Imaging, Image quality, Super-resolution, iOCT
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10163972
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