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Hypothermic organ perfusion in the 2020s: mixing the benefits of low temperatures and dynamic flow outside the body

Cherkashina, D; Petrenko, O; Fuller, B; (2022) Hypothermic organ perfusion in the 2020s: mixing the benefits of low temperatures and dynamic flow outside the body. Cryo Letters , 43 (5) pp. 255-263. 10.54680/fr22510110112. Green open access

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Abstract

The cold chain supply of donor organs for transplantation has been an integral part of the delivery of transplant clinical services over the past five decades. Within the technologies used for this, hypothermic machine perfusion (HMP) was a concept, which was attractive to maintain organs under optimal conditions outside the body, and many early research studies on HMP were reported. However, it took the arrival of important new concepts to ensure that HMP was logistically feasible and valuable from an organ physiology perspective within the clinical pathways. This review provides details of the current status of HMP across the range of organs transplanted in the clinic, and discusses what new areas might benefit from applying HMP in coming years. In conclusion, HMP is now being used more frequently for clinical organ preservation in a variety of settings. As new therapies such as cell or gene therapy become more common, HMP will continue to play an important facilitator role for optimising organs in the donor pathway.

Type: Article
Title: Hypothermic organ perfusion in the 2020s: mixing the benefits of low temperatures and dynamic flow outside the body
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.54680/fr22510110112
Publisher version: https://doi.org/10.54680/fr22510110112
Language: English
Additional information: This article is Open Access under the terms of the Creative Commons CC BY-NC-ND licence.
Keywords: Dynamic cold perfusion; hypothermic machine perfusion; organ perfusion systems; organ preservation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10163890
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