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The evolutionary tuning of hearing

Lipovsek, Marcela; Elgoyhen, Ana Belén; (2023) The evolutionary tuning of hearing. Trends in Neurosciences 10.1016/j.tins.2022.12.002. (In press). Green open access

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Abstract

After the transition to life on land, tympanic middle ears emerged separately in different groups of tetrapods, facilitating the efficient detection of airborne sounds and paving the way for high frequency sensitivity. The processes that brought about high-frequency hearing in mammals are tightly linked to the accumulation of coding sequence changes in inner ear genes; many of which were selected during evolution. These include proteins involved in hair bundle morphology, mechanotransduction and high endolymphatic potential, somatic electromotility for sound amplification, ribbon synapses for high-fidelity transmission of sound stimuli, and efferent synapses for the modulation of sound amplification. Here, we review the molecular evolutionary processes behind auditory functional innovation. Overall, the evidence to date supports the hypothesis that changes in inner ear proteins were central to the fine tuning of mammalian hearing.

Type: Article
Title: The evolutionary tuning of hearing
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tins.2022.12.002
Publisher version: https://doi.org/10.1016/j.tins.2022.12.002
Language: English
Additional information: © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: hair cells, inner ear, molecular evolution, prestin, α9α10 nicotinic receptor
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10163649
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