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Extracting spacing-derived estimates of rod density in healthy retinae

Heitkotter, H; Patterson, EJ; Woertz, EN; Cava, JA; Gaffney, M; Adhan, I; Johnny, TAM; ... Carroll, J; + view all (2023) Extracting spacing-derived estimates of rod density in healthy retinae. Biomedical Optics Express , 14 (1) pp. 1-17. 10.1364/BOE.473101. Green open access

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Abstract

Quantification of the rod photoreceptor mosaic using adaptive optics scanning light ophthalmoscopy (AOSLO) remains challenging. Here we demonstrate a method for deriving estimates of rod density and rod:cone ratio based on measures of rod spacing, cone numerosity, and cone inner segment area. Twenty-two AOSLO images with complete rod visualization were used to validate this spacing-derived method for estimating density. The method was then used to estimate rod metrics in an additional 105 images without complete rod visualization. The spacing-derived rod mosaic metrics were comparable to published data from histology. This method could be leveraged to develop large normative databases of rod mosaic metrics, though limitations persist with intergrader variability in assessing cone area and numerosity.

Type: Article
Title: Extracting spacing-derived estimates of rod density in healthy retinae
Open access status: An open access version is available from UCL Discovery
DOI: 10.1364/BOE.473101
Publisher version: https://doi.org/10.1364/BOE.473101
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10163387
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