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Management of neonatal central nervous system viral infections: Knowledge gaps and research priorities

Abeywickrema, Movin; Kelly, Dominic; Kadambari, Seilesh; (2023) Management of neonatal central nervous system viral infections: Knowledge gaps and research priorities. Reviews in Medical Virology , Article e2421. 10.1002/rmv.2421. (In press). Green open access

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Abstract

Congenital CMV, enteroviruses, human parechovirus and herpes simplex virus are all common causes of severe central nervous system (CNS) infection in neonates. The introduction of screening (i.e. newborn hearing screening programme), integration of molecular syndromic testing (i.e. multiplex polymerase chain reaction assays) and increase in sexually transmitted infections (i.e. anogenital herpes) have contributed to increases in each of these infections over the last decade. However, therapeutic options are highly limited in part due to the lack of epidemiological data informing trials. This review will describe our current understanding of the clinical burden and epidemiology of these severe neonatal CNS infections, outline the novel antiviral and vaccines in the pipeline and suggest future research studies which could help develop new therapeutics.

Type: Article
Title: Management of neonatal central nervous system viral infections: Knowledge gaps and research priorities
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/rmv.2421
Publisher version: https://doi.org/10.1002/rmv.2421
Language: English
Additional information: © 2023 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: CMV, antiviral, enterovirus, herpes simplex virus, parechovirus, vaccine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10163383
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