Taha, K; Kirkels, FP; Teske, AJ; Asselbergs, FW; van Tintelen, JP; Doevendans, PA; Kutty, S; ... Cramer, MJ; + view all Taha, K; Kirkels, FP; Teske, AJ; Asselbergs, FW; van Tintelen, JP; Doevendans, PA; Kutty, S; Haugaa, KH; Cramer, MJ; - view fewer (2022) Echocardiographic Deformation Imaging for Early Detection of Genetic Cardiomyopathies: JACC Review Topic of the Week. Journal of the American College of Cardiology , 79 (6) pp. 594-608. 10.1016/j.jacc.2021.11.045.

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Abstract

Clinical screening of the relatives of patients with genetic cardiomyopathies is challenging, as they often lack detectable cardiac abnormalities at presentation. Life-threatening adverse events can already occur in these early stages of disease, so sensitive tools to reveal the earliest signs of disease are needed. The utility of echocardiographic deformation imaging for early detection has been explored for this population in multiple studies but has not been broadly implemented in clinical practice. The authors discuss contemporary evidence on the utility of deformation imaging in relatives of patients with genetic cardiomyopathies. The available body of data shows that deformation imaging reveals early disease-specific abnormalities in dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmogenic cardiomyopathy. Deformation imaging seems promising to enhance the screening and follow-up protocols in relatives, and the authors propose measures to accelerate its implementation in clinical care.

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