Musvosvi, Munyaradzi;
Huang, Huang;
Wang, Chunlin;
Xia, Qiong;
Rozot, Virginie;
Krishnan, Akshaya;
Acs, Peter;
... GC6-74, Consortium; + view all
(2023)
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection.
Nature Medicine
10.1038/s41591-022-02110-9.
(In press).
Preview |
PDF
s41591-022-02110-9.pdf - Published Version Download (9MB) | Preview |
Abstract
Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against Mycobacterium tuberculosis, but the ability to broadly study these responses has been limited. In the present study, we used single-cell and bulk T cell receptor (TCR) sequencing and the GLIPH2 algorithm to analyze M. tuberculosis-specific sequences in two longitudinal cohorts, comprising 166 individuals with M. tuberculosis infection who progressed to either tuberculosis (n = 48) or controlled infection (n = 118). We found 24 T cell groups with similar TCR-β sequences, predicted by GLIPH2 to have common TCR specificities, which were associated with control of infection (n = 17), and others that were associated with progression to disease (n = 7). Using a genome-wide M. tuberculosis antigen screen, we identified peptides targeted by T cell similarity groups enriched either in controllers or in progressors. We propose that antigens recognized by T cell similarity groups associated with control of infection can be considered as high-priority targets for future vaccine development.
| Type: | Article |
|---|---|
| Title: | T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41591-022-02110-9 |
| Publisher version: | https://doi.org/10.1038/s41591-022-02110-9 |
| Language: | English |
| Additional information: | © 2023 Springer Nature Limited. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Adolescent Cohort Study team, GC6-74 Consortium |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10163079 |
Archive Staff Only
 |
View Item |
