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Pragmatic trials for critical illness in neonates and children

Schlapbach, Luregn J; Peters, Mark J; (2023) Pragmatic trials for critical illness in neonates and children. The Lancet Child and Adolescent Health , 7 (2) pp. 78-79. 10.1016/s2352-4642(22)00345-5. Green open access

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Abstract

More than 100 000 infants and children are admitted to neonatal and paediatric intensive care units in the UK annually. Infections and sepsis remain a leading cause of admission, short-term and long-term morbidity, and mortality in this patient group. Yet, the majority of diagnostic and therapeutic practices in this setting are not based on high-grade evidence. This exposes children to suboptimal decision making and ineffective or even harmful interventions. The cost to patients, families, and society of this evidence deficit is unknown. Is this simply attributable to the innate challenges of performing clinical trials (cost, time, and availability of appropriately trained staff) or rather to the specific critical care setting (time-sensitive interventions, safety concerns, acceptability to staff and parents, and the complexity of consent under acute stress)?

Type: Article
Title: Pragmatic trials for critical illness in neonates and children
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/s2352-4642(22)00345-5
Publisher version: https://doi.org/10.1016/s2352-4642(22)00345-5
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10162760
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