Baldwin, Jessie R;
Sallis, Hannah M;
Schoeler, Tabea;
Taylor, Mark J;
Kwong, Alex SF;
Tielbeek, Jorim J;
Barkhuizen, Wikus;
... Pingault, Jean-Baptiste; + view all
(2022)
A genetically informed Registered Report on adverse childhood experiences and mental health.
Nature Human Behaviour
10.1038/s41562-022-01482-9.
(In press).
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Abstract
Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the United Kingdom and the United States to investigate gene-environment correlations and genetic confounding of the associations between ACEs and mental health. Regarding gene-environment correlations, children with higher polygenic scores for mental health problems had a small increase in odds of ACEs. Regarding genetic confounding, elevated risk of mental health problems in children exposed to ACEs was at least partially due to pre-existing genetic risk. However, some ACEs (such as childhood maltreatment and parental mental illness) remained associated with mental health problems independent of genetic confounding. These findings suggest that interventions addressing heritable psychiatric vulnerabilities in children exposed to ACEs may help reduce their risk of mental health problems.
| Type: | Article |
|---|---|
| Title: | A genetically informed Registered Report on adverse childhood experiences and mental health |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41562-022-01482-9 |
| Publisher version: | https://doi.org/10.1038/s41562-022-01482-9 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. This research was funded in whole, or in part, by the Wellcome Trust [grant 215917/Z/19/Z]. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10162747 |
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