Zaidi, A;
Harris, R;
Hall, J;
Woodhall, S;
Andrews, N;
Dunbar, K;
Lopez-Bernal, J;
(2023)
Effects of Second Dose of SARS-CoV-2 Vaccination on Household Transmission, England.
Emerging infectious diseases
, 29
(1)
pp. 127-132.
10.3201/eid2901.220996.
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Abstract
A single SARS-CoV-2 vaccine dose reduces onward transmission from case-patients. We assessed the potential effects of receiving 2 doses on household transmission for case-patients in England and their household contacts. We used stratified Cox regression models to calculate hazard ratios (HRs) for contacts becoming secondary case-patients, comparing contacts of 2-dose vaccinated and unvaccinated index case-patients. We controlled for age, sex, and vaccination status of case-patients and contacts, as well as region, household composition, and relative socioeconomic condition based on household location. During the Alpha-dominant period, HRs were 0.19 (0.13-0.28) for contacts of 2-dose BNT162b2-vaccinated case-patients and 0.54 (0.41-0.69) for contacts of 2-dose Ch4dOx1-vaccinated case-patients; during the Delta-dominant period, HRs were higher, 0.74 (0.72-0.76) for BNT162b2 and 1.06 (1.04-1.08) for Ch4dOx1. Reduction of onward transmission was lower for index case-patients who tested positive ≥2 months after the second dose of either vaccine.
| Type: | Article |
|---|---|
| Title: | Effects of Second Dose of SARS-CoV-2 Vaccination on Household Transmission, England |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3201/eid2901.220996 |
| Publisher version: | https://doi.org/10.3201/eid2901.220996 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | household, respiratory infections, severe acute respiratory syndrome coronavirus 2, transmission, vaccination, viruses, zoonoses, Humans, COVID-19 Vaccines, BNT162 Vaccine, SARS-CoV-2, COVID-19, Vaccination, England |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10162668 |
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