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Anatomy and embryology of tracheo-esophageal fistula

Durkin, N; De Coppi, P; (2022) Anatomy and embryology of tracheo-esophageal fistula. Seminars in Pediatric Surgery , 31 (6) , Article 151231. 10.1016/j.sempedsurg.2022.151231. Green open access

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Abstract

Anomalies in tracheo-esophageal development result in a spectrum of congenital malformations ranging from, most commonly, esophageal atresia with or without trachea-esophageal fistula (EA+/-TEF) to esophageal web, duplication, stricture, tracheomalacia and tracheal agenesis. Despite the relative frequency of EA, however, the underlying etiology remains unknown and is likely due to a combination of genetic, epigenetic and environmental factors. In recent years, animal models have dramatically increased our understanding of the molecular and morphological processes involved in normal esophageal development during the key stages of anterior-posterior regionalization, dorsal-ventral patterning and morphogenic separation. Moreover, the use of animal models in conjunction with increasingly advanced techniques such as genomic sequencing, sophisticated live imaging studies and organoid models have more recently cast light on potential mechanisms involved in EA pathogenesis. This article aims to unravel some of the mysteries behind the anatomy and embryology of EA whilst providing insights into future directions for research.

Type: Article
Title: Anatomy and embryology of tracheo-esophageal fistula
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.sempedsurg.2022.151231
Publisher version: https://doi.org/10.1016/j.sempedsurg.2022.151231
Language: English
Additional information: © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Esophagus, Tracheo-esophageal fistula, Development, Morphogenesis, Anatomy, Classification
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10162608
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